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May 7, 2022 · Therefore, DCs are deeply involved in the pathogenesis of various autoimmune diseases and cancer. For example, in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and ulcerative colitis, DCs lose their immunosuppressive function and exhibit a pro-inflammatory phenotype ( 25, 26 ).
May 20, 2022 · Extrahepatic delivery of small interfering RNAs (siRNAs) may have applications in the development of novel therapeutic approaches. However, reports on such approaches are limited, and the scarcity of reports concerning the systemically targeted delivery of siRNAs with effective gene silencing activi ….
Jan 12, 2022 · Abstract. Extrahepatic targeted delivery of oligonucleotides, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASOs), is an attractive technology for the development of nucleic acid-based medicines.
Keiji Uehara 1,*, Toshimasa Harumoto1, Asana Makino1, Yasuo Koda1, Junko Iwano2, Yasuhiro Suzuki 1 , Mari Tanigawa 1 ,HirotoIwai 1 , Kana Asano 1 , Kana Kurihara 1 , Akinori Hamaguchi 1 , Hiroshi ...
Jun 11, 2014 · CANCER. RNAi Therapies: Drugging the Undruggable. New strategies are required to make RNA interference therapeutics a viable tool for cancer management. Sherry Y. Wu, Gabriel Lopez-Berestein. , George A. Calin, and Anil K. Sood Authors Info & Affiliations. Science Translational Medicine. 11 Jun 2014. Vol 6, Issue 240. p. 240ps7.
- Sherry Y. Wu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood
- 2014
Extrahepatic delivery of small interfering RNAs (siRNAs) may have applications in the development of novel therapeutic approaches. However, reports on such approaches are limited, and the scarcity of reports concerning the systemically targeted delivery of siRNAs with effective gene silencing activity presents a challenge. We herein report for the first time the targeted delivery of CD206 ...
May 7, 2022 · CMM–siRNA exhibited a strong binding ability to CD206 and selectively delivered contents to CD206-expressing macrophages and DCs. Furthermore, the conjugates demonstrated strong gene silencing ability with long-lasting effects and protein downregulation in CD206-expressing cells in vivo.
