2009
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Paul Bunnell is a Burbank-born filmmaker who has worked on various genres and projects, such as The Ghastly Love of Johnny X, Lemony Snicket's A Series of Unfortunate Events, and Pee-wee's Big Holiday. See his biography, awards, credits, photos, videos, and trivia on IMDb.
- January 1, 1
- 1.73 m
- Glendale, California, USA
Learn about the Paul Bunnell test, a heterophil antibody test for glandular fever diagnosis. Find out how it works, its pattern of reactivity and its limitations.
It is an improvement on the Paul–Bunnell test. The test is specific for heterophile antibodies produced by the human immune system in response to EBV infection. Commercially available test kits are 70–92% sensitive and 96–100% specific , with a lower sensitivity in the first two weeks after clinical symptoms begin.
- Sample
- Principle
- Accuracy of Monospot Test
- Uses of Monospot Test
Serum/Plasma:Serum or plasma may be used with the monospot test, provided an acceptable medical technique collects whole blood. Avoid using grossly hemolyzed sera. The serum should be clear and free of bacterial contamination. Specimens can be stored at 2 to 8°C for 24 hours. For prolonged storage, specimens should be frozen (-20°C).
A sample of the patient’s serum or plasma is placed on a microscope slide and mixed with guinea pig kidney antigen and preserved horse erythrocytes (these reagents can be purchased from commercial suppliers of kits). Thoroughly mix the reagents and rock the slide for a minute. Suppose heterophil antibodies are present in the serum/plasma and the bl...
Studies have shown that monospot test produces both false-positive and false-negative results. Results should be correlated with clinical and hematological findings. 1. False Positive Reactions: The antibodies detected by monospot can be caused by conditions other than infectious mononucleosis. It may occur in persons with: 1.1. Leukemia or lymphom...
The monospot test is not recommended for general use. Monospot test may indicate that a person has a typical case of infectious mononucleosis, but does not confirm the presence of EBV infection. References and further readings 1. Marshall-Andon T, Heinz P. How to use … the Monospot and other heterophile antibody tests. Archives of Disease in Childh...
Paul Bunnell is an actor, writer, producer and director who was born in a movie theater in Burbank, California. He has worked on various sci-fi and horror films, such as The Ghastly Love of Johnny X, and was an extra in Tim Burton's Planet of the Apes.
- August 9, 1963
Learn about the test for infectious mononucleosis (IM), also known as glandular fever or Paul Bunnell syndrome, caused by Epstein-Barr virus (EBV). Find out how to collect and send the sample, the turnaround time, and the reference ranges.
Jun 18, 2024 · Paul Bunnell test is used to find heterophil antibodies in cases of infectious mononucleosis. Specially prepared sheep red blood cells are used for this test. These are added to patient blood samples with heterophile antibodies when clumping or aggregating.
