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  1. Stiff-person syndrome (SPS), also known as stiff-man syndrome, is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms , resulting in postural deformities.

  2. Stiff person syndrome is a rare autoimmune neurological disorder that most commonly causes muscle stiffness and painful spasms that come and go and can worsen over time. However, some people experience other symptoms such as an unsteady gait, double vision or slurred speech. SPS symptoms are thought to be related to which type of SPS a person has.

  3. Jun 10, 2024 · Stiff person syndrome is a rare, chronic condition that causes muscle stiffness and painful muscle spasms. The severity of symptoms varies from person to person. There’s no cure for stiff person syndrome, but treatment can help manage symptoms and slow the progression of the condition.

  4. Stiff-person syndrome (SPS) is a rare, progressive neurological disorder. Symptoms may include stiff muscles in the trunk (torso), arms, and legs; and greater sensitivity to noise, touch, and emotional distress, which can set off muscle spasms.

  5. Jul 11, 2023 · Stiff person syndrome (SPS) is a rare acquired neurological disorder that most often causes progressive muscle stiffness (rigidity) and repeated episodes of painful muscle spasms. Muscular rigidity often fluctuates (i.e., grows worse and then improves) and usually occurs along with the muscle spasms.

  6. Dec 8, 2022 · Stiff-person syndrome is an autoimmune disorder of the nervous system, often resulting in progressive, severe muscle stiffness and spasms of the lower extremities and back. It also can affect other body regions.

  7. Stiff Person Syndrome is an autoimmune and neurological disorder that causes rigidity and spasms in the trunk and limbs. Learn about symptoms and treatment.

  8. Jul 10, 2023 · Stiff person syndrome (SPS) is a rare progressive and often underdiagnosed immune-mediated disorder of the central nervous system characterized by progressive rigidity and triggered painful spasms of predominantly axial and proximal limb muscles.

  9. Stiff-person syndrome (formerly called stiff-man syndrome) affects the central nervous system (CNS) but has neuromuscular manifestations. Most patients with stiff-person syndrome have antibodies against glutamic acid decarboxylase (GAD), the enzyme involved in the production of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid).

  10. Stiff Person Syndrome (SPS) is a neurological disease with autoimmune features. Usually progressive over time, SPS symptoms include severe muscle spasms, rigid limbs and body, debilitating pain, and chronic anxiety. We're on a mission to END SPS! Learn About SPS. Our Mission.