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T follicular helper cells (Tfh) are a specialized subset of CD4 + T cells that were first identified in the human tonsil. They play a critical role in protective immunity helping B cells produce antibody against foreign pathogens.
Apr 12, 2010 · A fundamental function of T helper (Th) cells is to regulate B-cell proliferation and immunoglobulin class switching, especially in the germinal centers. Th1 and Th2 lineages of CD4 + T cells have...
Jul 2, 2012 · In recent years, T follicular helper (Tfh) cells have emerged as the key cell type required for the formation of GCs and the generation of long-lived serological memory ( Vinuesa et al., 2005b; King et al., 2008; Crotty, 2011 ).
Jul 11, 2022 · Follicular helper T (T FH) cells support germinal center (GC) formation and regulate clonal selection and differentiation of memory and antibody-secreting B cells, thus controlling antibody...
Jul 7, 2021 · T follicular helper (T FH) cells are crucial for B cell-mediated humoral immunity 1. Although transcription factors such as BCL6 drive the differentiation of T FH cells 2, 3, it is unclear...
What is a T follicular helper (Tfh) cell? T follicular helper (Tfh) cells are a subset of CD4-positive T helper cells that are involved in the humoral response [ 1 ]. Tfh cells are found in secondary lymphoid tissues, including tonsils, spleen, and lymph nodes.
Follicular helper T cells (also known as T follicular helper cells and abbreviated as TFH ), are antigen -experienced CD4 + T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches, and are identified by their constitutive expression of the B cell follicle ...
