Sara Bellaïche
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Oct 3, 2023 · Staggered overdose: excessive amounts of paracetamol ingested over longer than 1 hour; usually in the context of self-harm. Therapeutic excess: Excessive paracetamol taken with intent to treat pain or fever and without self-harm intent. Paracetamol ingested at a dose greater than the licensed daily dose AND ≥75 mg/kg/24 hours.
Mar 22, 2022 · Amphetamine overdose represents a large burden of dependency and toxicity worldwide, stemming from both legitimate and recreational ingestion of amphetamine and its derivatives by nearly 36 million users annually. Overdose and toxicity strike inconsistently among new, occasional, chronic, and binge users. Intentional overdose is also encountered.
Apr 22, 2024 · Benzodiazepine overdose can be intentional (e.g., as an act of self-harm), as part of recreational misuse, or accidental (e.g., medication error). Benzodiazepines are the most commonly prescribed medications for anxiety, sedation, and sleep. The key feature of overdose is excessive sedation. Larger doses can cause coma, respiratory depression ...
Jun 18, 2020 · The recommended dose of paracetamol is 4 g (or 75 mg/kg) in 24 hours for an adult patient. Any ingestion exceeding this is regarded as an overdose. However, toxicity is extremely unlikely if <75 mg/kg paracetamol has been ingested within a 24-hour period. Single acute overdose is defined as an ingestion of >4 g (or >75 mg/kg) in a period of <1 ...
Aug 9, 2024 · Opioid overdose occurs when a person takes opioids in larger quantities than are physically tolerated. Signs include central nervous system and respiratory depression, miosis, and apnoea. The patient's history from bystanders/friends/family can assist diagnosis. Initial treatment consists of ensuring adequate ventilation and consideration of ...
Aug 1, 2023 · Overdose can be intentional (e.g., as an act of self-harm), as part of recreational misuse, or accidental (e.g., medication error). The key feature of overdose is excessive sedation. Larger doses can cause coma, respiratory depression, and, without appropriate treatment, even death, particularly in the context of mixed ingestion with other CNS depressants.
Jan 25, 2023 · Definition. An acute acetaminophen overdose in adults, in terms of FDA-labeled therapeutic dosing, is minimally defined as a cumulative dose of acetaminophen >4 g ingested over 8 hours or less (some authors use a period of 4 hours). [1] Fontana RJ, Liou I, Reuben A, et al. AASLD practice guidance on drug, herbal, and dietary supplement-induced ...
Apr 5, 2024 · Tricyclic antidepressant overdose should be suspected in patients with a history of depression, suicidality, and overdose presenting with a sudden deterioration in mental status and vital signs. At 1 to 2 hours after ingestion, there is a rapid decline in mental and cardiovascular status. Diagnosis is established on clinical grounds and classic ...
Dec 19, 2023 · Benzodiazepine (BZD) overdose occurs when excessive amounts of BZD medications are taken. Commonly known as minor tranquilizers or sleeping pills, BZDs are prescribed for sedative, anxiolytic, hypnotic, and anticonvulsant purposes. BZDs are also widely abused. Acute overdose is characterized by excessive sedation with impaired mental status ...
Sep 10, 2024 · Cocaine is a type IC anti-dysrhythmic, local anaesthetic, and sympathomimetic. Cocaine toxicity refers to adverse events that occur in the setting of cocaine use. These events, which can occur in combination or isolation, include hyperthermia, rhabdomyolysis, dysrhythmia, ischaemia, intracranial haemorrhage, agitation, psychosis, and seizures.
