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Mar 21, 2023 · What is acute myeloid leukemia (AML)? Acute myeloid leukemia (AML) is a rare cancer that affects your bone marrow and blood. It typically happens when certain genes or chromosomes mutate (change). AML usually affects people age 60 and older, but it can also affect younger adults and children.
Feb 26, 2021 · Acute myeloid leukaemia (AML) is also called acute myelogenous or myelocytic leukaemia. AML is responsible for about 25% of childhood leukaemias, often developing in infancy. However, the incidence of AML increases with age. It is the most common acute leukaemia in adults, with a median age of onset of 68 years. 1.
Sep 19, 2024 · The understanding of the molecular pathobiology of acute myeloid leukemia (AML) has spurred the identification of therapeutic targets and the development of corresponding novel targeted...
Acute myeloid leukemia is also called acute myelocytic leukemia, acute myelogenous leukemia, acute granulocytic leukemia, acute non-lymphocytic leukemia, or sometimes just AML. It is most common in older people.
6 days ago · Acute Myeloid Leukemia (AML) is one of the most challenging hematological malignancies and is characterized by clonal expansion of myeloid blasts in the bone marrow (BM) often leading to circulating blasts in peripheral blood [].The uncontrolled growth of blasts leads to the suppression of normal hematopoiesis, causing BM failure and impairing the production of normal blood cells [].
Jun 19, 2024 · Acute myeloid leukemia (AML; formerly called acute myelogenous leukemia) refers to a diverse group of aggressive hematologic malignancies involving the proliferation of leukemic blasts committed to the granulocytic, monocytic, erythroid, or megakaryocytic lineages. AML is characterized by a clonal proliferation of myeloid precursors with a ...
2 days ago · CAR T cell therapy has demonstrated efficacy in treating B-cell malignancies, achieving high response rates and durable remissions. However, translating this success to acute myeloid leukemia (AML ...
Sep 30, 2024 · Acute myeloid leukemia (AML) is the most common and lethal leukemia in adults. AML consists of many genetic subtypes which limits broad applicability of targeted therapy. We discovered that the hematopoietic restricted tetraspanin CD37 is expressed on all primary AML blasts and thus may represent a common therapeutic target for AML regardless of subtype.
6 days ago · Acute myeloid leukemia (AML), a cancer that results from the clonal expansion of genetically altered hematopoietic stem cells and hematopoietic progenitor cells in the bone marrow 1, is ...
Jul 19, 2024 · Recent developments in menin inhibitors for relapsed or refractory acute myeloid leukemia (AML) were highlighted at the 2023 ASH Annual Meeting. Notably, revumenib showed promising efficacy, achieving a 100% ORR when combined with decitabine/cedazuridine and venetoclax.
