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  1. DEPLETE definition: 1. to reduce something in size or amount, especially supplies of energy, money, etc.: 2. to reduce…. Learn more.

  2. The meaning of DEPLETE is to empty of a principal substance. How to use deplete in a sentence. Did you know? Synonym Discussion of Deplete.

  3. to reduce something in size or amount, especially supplies of energy, money, etc.: If we continue to deplete the earth's natural resources, we will cause serious damage to the environment. The illness depletes the body of important vitamins.

  4. Deplete definition: to decrease seriously or exhaust the abundance or supply of. See examples of DEPLETE used in a sentence.

  5. 3 meanings: 1. to use up (supplies, money, energy, etc); reduce or exhaust 2. to empty entirely or partially 3. medicine to.... Click for more definitions.

  6. deplete (something) to reduce something by a large amount so that there is not enough left; to be reduced by a large amount. Food supplies were severely depleted. Supplies are depleting fast.

  7. To deplete is to use up or consume a limited resource. Visiting relatives might deplete your refrigerator of food, or a pestering friend might deplete your patience. The verb deplete is used like “to drain.”.