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  1. 1 day ago · Introduction. As a major driver of genomic instability, homologous recombination deficiency (HRD) occurs frequently in human cancers (e.g., ∼50% in ovarian cancer). 1, 2, 3 It has attracted wide interest because of synthetic lethality, wherein this defect renders tumors vulnerable to poly (ADP-ribose) polymerase (PARP) inhibition. 4, 5 Multiple PARP inhibitors have been approved for the ...

  2. 6 days ago · Topalian SL, Taube JM, Anders RA, et al. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016;16:275-287.

  3. 3 days ago · The other recipients included Massachusetts State Senator Michael J. Rodrigues, Leon J. Topalian, CEO of Nucor (the largest steel manufacturer in North America), and Brigadier General Enoch “Woody” Woodhouse, the last surviving member of the Tuskegee Airmen, a distinguished group of all-Black military aviators who served with distinction in World War II.

  4. 3 days ago · United States. The United States women's national artistic gymnastics team represents the United States in FIG international competitions. As of 2023, the U.S. team is the reigning World team champion and the reigning Olympic team silver medalists, with the four gymnasts nicknamed the "Fighting Four". [1]

  5. iapsp.org › about-the-international-association-forIAPSP Leadership - IAPSP

    Jun 27, 2024 · IAPSP Leadership. · Current Executive Board of the IAPSP. · Advisory Board of the International Council. · International Council Members.

  6. 3 days ago · Leon J. Topalian, a member of the Massachusetts Maritime Academy Class of ’91, and Chair, President, and Chief Executive Officer of Nucor, the largest recycler and manufacturer of steel and steel products in North America, provided the keynote speech for the ceremony, weaving his alumnus perspective within three key points he ...

  7. 5 days ago · Topalian SL, Hodi S, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD 1 antibody in cancer. N Engl J Med. 2012;366:2443-2454. Abstract