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  1. Jul 12, 2024 · micro RNAs (miRNAs) are a type of non-coding RNA (ncRNA), ~21 24 nucleotides in length, that function in the post-transcriptional regulation of gene expression. Typically miRNAs interact with...

  2. Jul 2, 2024 · When the target gene(s) of a miRNA have a positive role for both development and defense (Scenarios I and V), the aim is to enhance the expression of the target(s), which is achievable by using constitutive/inducible promoter or CRISPR/Cas-mediated insertion of enhancer in promoter (Claeys et al., 2024), by creating miRNA-cleavage-resistant ...

    • Enhui Shen, Tianlun Zhao, Qian-Hao Zhu
    • 02 July 2024
  3. Jul 7, 2024 · MiRNAs may serve as diagnostic and prognostic biomarkers, as well as potential therapeutic targets for colorectal cancer. In recent years, there has been increasing evidence for an epigenetic interaction between DNA methylation and miRNA expression in tumours.

  4. 2 days ago · How to analyze miRNA-seq datasets alone or both miRNA and corresponding mRNA datasets together; How to use QIAGEN IPA without a dataset, using miRNA IDs; Introduction to databases and curated content specific to miRNA; How to effectively apply various filters and functionalities to identify biomarkers, key targets and biological mechanisms

  5. Jul 2, 2024 · We have reconstructed the landscape of miRNA production, providing an encyclopaedia for understanding miRNA biogenesis in A. thaliana and offering a strategy for designing artificial miRNAs...

  6. Jul 13, 2024 · MicroRNAs (miRNAs) are small non-coding RNA molecules mostly known for their role as post-transcriptional regulators of gene expression and for mediating several physiological functions including cell differentiation, development, metabolism and homeostasis maintenance.

  7. Jul 16, 2024 · scanMiR implements aggregation of miRNA sites based on the biochemical model from McGeary, Lin et al. (2019). This model first predicts the occupancy of AGO-miRNA complexes at each potential binding site as a function of the measured or estimated dissociation constants (Kds).

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