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Sep 12, 2023 · Learn about the causes, symptoms, and management of metformin overdose, a common antidiabetic drug that can cause lactic acidosis. This article is for health care professionals and requires subscription to access.
- Jason Chu, MD
Metformin poisoning. Authors Jason Chu, MD Associate...
- Jason Chu, MD
- Metformin Maximum Daily Intake
- Common Symptoms of Metformin Overdose
- Overdose on Metformin Side Effects
- Metformin Overdose Risks: Lactic Acidosis
- What to Do If One Has Overdosed on Metformin
- Treatment For A Metformin Overdose
- Are There Any Long-Term Effects After Overdosing on Metformin?
- Conclusion
The common dosage for metformin ranges from 500 milligrams to a maximum of 2,550 milligrams per day. It’s usually in pill form and recommended to split the dose among meals, typically three times per day.
Based on case studies of metformin overdoses, the most common symptoms of a metformin overdose include: 1. Nausea 2. Vomiting 3. Diarrhea 4. Epigastric pain 5. Increased thirst 6. Reduced appetite 7. Lethargy 8. Increased breathing rate 9. Hypotension (low blood pressure) 10. Hypothermia 11. Acute renal failure 12. Coma 13. Cardiac arrest
Metformin comes in tablet form and usually involves taking several tablets each day. Taking medications comes with a risk of overdose, such as accidentally taking more tablets than you’re prescribed. Drug overdoses can be accidental or intentional – intentional drug overdoses are usually part of a suicide attempt.
The main risk from overdosing on metformin is lactic acidosis. Lactic acidosisis a serious condition where your body creates more lactic acid than your body can clear. The symptoms of lactic acidosisusually set in quickly and include: 1. Abdominal or stomach discomfort 2. Decreased appetite 3. Diarrhea 4. Fast, shallow breathing 5. Discomfort 6. Mu...
The maximum daily dose of metformin is 2550 mg. If you think you’ve overdosed on metformin, you should contact the Poison Control Centers at (800) 222-1222. Seek emergency medical care if symptoms of an overdose are being shown. If you or the person you know becomes unconscious, you should call 911 immediately. The sooner you seek medical care; the...
If you seek medical attention for a potential metformin overdose, you’ll likely have several blood tests, such as blood glucose, serum lactate level, pH, anion gap, electrolytes, and more. The treatment for a metformin overdose will depend on the severity and symptoms presented. For lactic acidosis, intravenous sodium bicarbonate is the main treatm...
If your metformin overdose is minor, you’ll likely have no long-term effects. The risk of long-term consequences is higher for severe cases of metformin overdose, such as intentional overdoses. You might suffer from kidney or heart problems after a severe metformin overdose, among other potential issues.
Metformin overdose is possible but is considered rare overall. The most serious and fatal metformin overdose cases occured with intentional overdoses in suicide attempts. In some cases, the doses were 30,000 milligrams and higher, compared to a typical maximum dose of 2,550 milligrams. Taking an extra metformin tablet or two on occasion will likely...
Aug 8, 2022 · Metformin associated lactic acidosis (MALA) was the most commonly reported adverse effect present in 224 (92.6%) patients. Most of the patients presented with gastrointestinal and neurological symptoms and a significant number of patients had severe metabolic acidosis and hyperlactatemia.
- Deven Juneja, Prashant Nasa, Ravi Jain
- 2022/08/08
- 10.4239/wjd.v13.i8.654
The parents discovered the overdose around 6:30 a.m., about 5 ½ hours post-ingestion, when the patient began complaining of vomiting, diarrhea, thirst, abdominal pain and bilateral leg pain. Paramedics were called, who found the patient to be agitated with a fingerstick glucose level of 180 mg/dL.
- Jeffrey R. Suchard, Thomas A. Grotsky
- 2008
Mar 29, 2021 · Learn why metformin overdose can cause lactic acidosis, not hypoglycemia, and how to recognize and treat it. Find out the risk factors, kinetics, and mechanisms of metformin toxicity and the role of dialysis in severe cases.
Oct 3, 2021 · A comprehensive guide to the evaluation and management of metformin-associated lactic acidosis, a potentially life-threatening condition. Learn about the physiology, epidemiology, presentation, differential diagnosis, prognosis, and treatment options for metformin overdose.
Nov 3, 2020 · Metformin overdose is usually benign but doses > 10 grams are concerning. Lactic acidosis will occur in these individuals who are susceptible (renal, cardiac, respiratory failure) or in patients who have ingested co-ingestants or are on medications that impair cardiac and renal function.
