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EMP3 is a gene that encodes a protein involved in cell-cell interaction and cell proliferation. It is expressed in various tissues and has a tumor-suppressor-like role in regulating differentiation, apoptosis and development of cancer cells.
Aug 5, 2024 · EMP3 (Epithelial Membrane Protein 3 (MAM Blood Group)) is a Protein Coding gene. Diseases associated with EMP3 include Glioblastoma Mesenchymal Subtype and Endometrial Stromal Tumor. An important paralog of this gene is PMP22.
How has SG Enable advanced disability inclusion since the release of the 3 rd Enabling Masterplan (EMP3) five years ago? How will we work with partners to achieve this 2030 goal? Read on to find out!
Sep 12, 2021 · EMP3 negatively modulates BRCA1 and RAD51 expression, indicating EMP3 suppresses homologous recombination repair of DNA double-strand breaks.
- Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
- 2021
May 17, 2021 · EMP3 is a 163-amino acid tetraspan membrane protein (~18 kDa) encoded by the EMP3 gene in the human chromosome 19q13.3 [23,24,25]. It belongs to the peripheral myelin protein 22-kDa (PMP22) gene family based on the sequence and structural homology [24,26].
- Antoni Andreu Martija, Stefan Pusch, Stefan Pusch
- 10.3390/ijms22105261
- 2021
- Int J Mol Sci. 2021 May; 22(10): 5261.
Nov 7, 2023 · BioID2-based proximity labeling revealed that EMP3 interacts with endocytic proteins involved in the vesicular transport of EGFR. EMP3 knockout (KO) enhances epidermal growth factor (EGF)-induced shuttling of EGFR into RAB7 + late endosomes, thereby promoting EGFR degradation.
Jul 16, 2020 · By whole-exome sequencing we identify EMP3, encoding epithelial membrane protein 3 (EMP3), as a candidate gene, then demonstrate inactivating mutations in ten known MAM-negative...
