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1 day ago · Flow-sorted F4/80 macrophages from the kidney were also analysed after peptide treatment examining the transcripts for Fn1 encoding fibronectin an ECM protein, C3ar1, the complement receptor, and ...
1 day ago · UMAP plot color-coded based on the expression of fibroblast marker genes COL1A1, COL1A2, COL3A1, and FN1. c. UMAP plot color-coded according to the LRRC15 expression in the UW (uninjured), PWD4 (post-wound day 4), PWD7 (post-wound day 7), and PWD12 (post-wound day 12) groups. d. Percentage of LRRC15+ fibroblasts at different time points. e.
1 day ago · The mRNA levels of ECM-related genes (COL3A1 and FN1) as well as COL1A1 were each positively correlated with atrial fibrosis-related gene expression. These results suggest that multiple signaling mechanisms are involved and linked in atrial fibrosis, reflected as an increase in ECM gene expression (COL1A1, COL3A1, FN1).
4 days ago · Background and purpose PD-1/PD-L1 inhibitors have become a promising therapy. However, the response rate is lower than 30% in patients with cervical cancer (CC), which is related to immunosuppressive components in tumor microenvironment (TME). Tumor-associated macrophages (TAMs), as one of the most important immune cells, are involved in the formation of tumor suppressive microenvironment ...
4 days ago · IL-12 is a key regulator of the T H 1 gene program in human and murine CD4 T cells ( 29, 41, 42 ). Hence, if IL-12 physiologically plays a role in the in vivo differentiation of human T fr cells, then this could be reflected by the presence of a T H 1 gene signature in bona fide T fr cells.
2 days ago · Heterotopic ossification of the elbow (HOE) is a complicated pathologic process characterized by extra bone formation in the elbow. Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells into osteoblasts. The aim of this study was to explore the ...
2 days ago · The mechanism and function of the expression of Schwann characteristics by nevus cells in the mature zone of the dermis are unknown. Early growth response 3 (EGR3) induces Schwann cell-like differentiation of melanoma cells by simulating the process of nevus maturation, which leads to a strong phenotypic transformation of the cells, including the formation of long protrusions and a decrease in ...
