Professor Nolter
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3 days ago · A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.
- Substitution
Substitution, as related to genomics, is a type of mutation...
- Point Mutation
A point mutation occurs in a genome when a single base pair...
- Missense Mutation
A missense mutation is a DNA change that results in...
- Daniel A. Gilchrist, Ph.D
Dr. Daniel Gilchrist joined the National Human Genome...
- Substitution
1 day ago · The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA ...
1 day ago · Many mutations, however, are deleterious or even lethal, and are removed from populations by natural selection. Genetic disorders are the result of deleterious mutations and can be due to spontaneous mutation in the affected individual, or can be inherited.
2 days ago · Moreover, RiceG2G provided new alleles of known genes, including missense mutations in RFT1 and GW6a as well as SVs in OsSOC1 and GNP1. By examining the cases of known genes that were not prioritized by RiceG2G, we found that the main limitation of RiceG2G was the lack of precise scoring of the effects of noncoding variants.
3 days ago · A point mutation occurs in a genome when a single base pair is added, deleted or changed. While most point mutations are benign, they can also have various functional consequences, including changes in gene expression or alterations in encoded proteins.
3 days ago · The JN.1 variant is a subvariant of Omicron variant BA.2.86 and contains several mutations that are associated with escape from vaccine-mediated immune protection. Emerging variants KP.2, KP.3 and LB.1 are descended from JN.1.
3 days ago · Relentless accumulation of somatic mutations renders mismatch repair (MMR)-deficient cancers immunogenic. The evolutionary strategies that these hypermutator tumors use to drive immune evasion ...
