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1 day ago · Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, et al. Mutational processes shape the landscape of TP53 mutations in human cancer. Nat Genet. 2018;50:1381–7.
1 day ago · This research aims to comprehensively explore building a multimodal foundation model for egocentric video understanding. To achieve this goal, we work on three fronts. First, as there is a lack of QA data for egocentric video understanding, we develop a data engine that efficiently generates 7M high-quality QA samples for egocentric videos ...
1 day ago · Knowledge is lacking on whether adolescents’ motivations for social media use predict internalizing symptoms, and few studies have considered the moderating role of extraversion. In 2017 (T1) and 2018 (T2), 197 adolescents (49.70% girls, Mage = 13.15, SD = 0.36) from a large metropolitan area participated in this study. Adolescents reported on their social media use motivations and ...
1 day ago · Solution-processable semiconductors allow scalable and cost-effective manufacturing of solid-state electronic devices. Nevertheless, the performance of transistors built on various semiconductors grown from solution, including silicon (), metal oxides (2–8), metal chalcogenides (9, 10), colloidal quantum dots (11–17), perovskites (18–20), one-dimensional (1D) or 2D nanomaterials (21–24 ...
11 hours ago · Background Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistance to conventional therapies, and dismal prognosis in patients. A deeper understanding of how components of the tumor microenvironment (TME) contribute to overall tumor organization and to programs of invasion may reveal opportunities for improved therapeutic ...
2 days ago · Bacterial meningitis is a potentially life-threatening disease in children that can lead to significant morbidity and mortality if not diagnosed and treated promptly (1). Infection can be caused by both Gram-positive and Gram-negative bacteria with the leading pathogens including Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae in older children and Escherichia coli ...
2 days ago · While the modulation of effector functions has been the major focus of PD-1 research, quick PD-1 upregulation in naïve T cells starting 1 h after priming raised a possibility that PD-1 also affects the development of effector T cells. The role of PD-1 in functional differentiation into Th1 and Th2 has been unclear.
