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Apr 27, 2023 · The MOE is a ratio of: the dose The total amount of a substance (e.g. a chemical or nutrient) given to, consumed or absorbed by an individual organism, population or ecosystem. at which a low but measurable adverse effect A change in the health, growth, behaviour or development of an organism that impairs its ability to develop or survive.
The margin of exposure (MOE) is a tool used in risk assessment to explore safety concerns arising from the presence of a potentially toxic substance in food or animal feed
Mar 30, 2012 · The MOE is a tool used by risk assessors to characterise the risk from exposure to genotoxic and carcinogenic substances, which may be found in food or feed. As such, the MOE approach provides an indication of the level of safety concern about a substance’s presence in food but it does not quantify the risk as such.
Mar 9, 2020 · EFSA was asked to deliver a scientific opinion on the risks to public health related to the presence of aflatoxins in food. The risk assessment was confined to aflatoxin B1 (AFB1), AFB2, AFG1, AFG2 and AFM1. More than 200,000 analytical results on the occurrence of aflatoxins were used in the evaluation. Grains and grain‐based products made the largest contribution to the mean chronic ...
May 5, 2022 · Based on the new data evaluated, the MOE approach is still considered appropriate, and an update of the 2015 Opinion is not required at the present time. EFSA was requested to deliver a statement on a recent publication revisiting the evidence for genotoxicity of acrylamide (AA). The statement was prepared by a Working Group and was endorsed by ...
May 13, 2020 · EFSA has published a scientific opinion on public health risks related to the presence of ochratoxin A (OTA) in food – a mycotoxin naturally produced by moulds that can be found in a variety of foodstuffs including cereals, preserved meats, fresh and dried fruit, and cheese. New data that have become available since the last assessment in 2006 suggest that OTA can be genotoxic by directly ...
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Mar 30, 2012 · The Scientific Committee is of the opinion that the MOE approach can be applied to impurities which are both genotoxic and carcinogenic, irrespective of their origin. The Scientific Committee reiterates its view expressed in 2005 that in general a margin of exposure of 10,000 or higher, if it is based on the BMDL10 from an animal study, and ...
Nov 8, 2011 · The MOE is a ratio of two factors which assesses for a given population Community of humans, animals or plants from the same species: the dose The total amount of a substance (e.g. a chemical or nutrient) given to, consumed or absorbed by an individual organism, population or ecosystem at which a small but measurable adverse effect A change in the health, growth, behaviour or development of an ...
Nov 3, 2005 · The MOE approach can therefore better support risk managers in defining possible actions required to keep exposure to such substance as low as possible. The Scientific Committee recommends that the MOE approach be utilised to assess the possible risks associated with genotoxic and carcinogenic substances found in food and feed, irrespective of their origin.
