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  1. 1 day ago · Importance Immuno-oncology agents have changed the treatment paradigm for metastatic renal cell carcinoma (mRCC). Such therapies improve survival but can impose considerable health care resource use (HCRU) and associated costs, necessitating their examination.

  2. 1 day ago · Rui Ai. Hangzhou Institute of Medicine (HIM), University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Chinese Academy of Sciences, Hangzhou, Zhejiang, PR China. School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, PR China. Contribution: Formal analysis (equal), Investigation (equal)

  3. 2 days ago · Triple-negative breast cancer (TNBC) is a highly lethal malignancy, and its clinical management encounters severe challenges due to its high metastatic propensity and the absence of effective therapeutic targets. To improve druggability of aurovertin B (AVB), a natural polyketide with a significant antiproliferative effect on TNBC, a series of NO donor/AVB hybrids were synthesized and tested ...

  4. 2 days ago · Despite the complexities of this arrangement, the tubeworm-microbes symbiosis is remarkably adaptive and productive (20, 21).Tubeworms often form high-density communities and dominate deep-sea chemosynthetic ecosystems (22, 23).

  5. 1 day ago · As an innovative, fundamental and scientific journal, Advances in Manufacturing aims to describe the latest regional and global research results and forefront ...

  6. 3 days ago · Rui Feng Chief Operating Officer. Ke Zhang Chief Human Resource Officer. Lun Feng Independent Director Nominee. Alan Jacobs Independent Director Nominee. Bin Wang Independent Director Nominee.

  7. 4 days ago · Agriculture is vital for economic growth in sub-Saharan Africa. In Rwanda and Zambia, the sector drives economic output, particularly the horticulture sector, which has emerged as a significant contributor to export revenue and employment for resource-poor rural communities. As agri-food value chains become globally connected, there are increasing concerns about food safety and both the social ...