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May 2, 2019 · Abstract. V (D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V (D)J recombination involve breaks at single recombination signal sequences (RSSs).
- Christopher M. Kirkham, James N.F. Scott, Xiaoling Wang, Alastair L. Smith, Adam P. Kupinski, Anthon...
- 2019
Christopher J. Kirkham, Ikutaro Hamada, Dorian A.H. Hanaor (Sep 23, 2022) e-Print: 2209.11513 [cond-mat.mtrl-sci] pdf DOI cite claim. reference search 0 citations ...
V(D)J recombination generates a hugely diverse repertoire of antigen receptors through the random joining of antigen receptor gene segments. Recombination is catalysed by the RAG proteins which bind to and cleave recombination signal sequences (RSSs) that flank each coding segment.
Christopher KIRKHAM, Postdoctoral Researcher | Cited by 190 | of University of Oxford, Oxford (OX) | Read 21 publications | Contact Christopher KIRKHAM
V(D)J recombination errors have long been associated with chromosome alterations in lymphoid cancers. Here, Kirkham et al. describe an unexpected reaction where the recombination by-product complexes with the RAG recombinase to trigger DNA breaks throughout the genome.
- Christopher M. Kirkham, James N.F. Scott, Xiaoling Wang, Alastair L. Smith, Adam P. Kupinski, Anthon...
- 2019
Christopher M. Kirkham, James N.F. Scott, Xiaoling Wang, ..., Peter G. Stockley, Roman Tuma, Joan Boyes Correspondence j.m.boyes@leeds.ac.uk In Brief V(D)J recombination errors have long been associated with chromosome alterations in lymphoid cancers. Here, Kirkham et al. describe an unexpected reaction where the recombination by-product ...
Sep 30, 2015 · A general model to calculate the spin-lattice (T1) relaxation time of blood, accounting for haematocrit, oxygen saturation and magnetic field strength - Patrick W Hales, Fenella J Kirkham, Christopher A Clark, 2016. Free access. Research article. First published online September 30, 2015.
