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Mar 25, 2016 · We mapped insulated neighborhoods in T cell acute lymphoblastic leukemia (T-ALL) and found that tumor cell genomes contain recurrent microdeletions that eliminate the boundary sites of insulated neighborhoods containing prominent T-ALL proto-oncogenes.
- Denes Hnisz, Abraham S. Weintraub, Daniel S. Day, Anne-Laure Valton, Rasmus O. Bak, Charles H. Li, J...
- 2016
Nov 4, 2019 · Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox & Job Dekker. Nature Cell Biology 21 , 1393–1402 ( 2019) Cite this article. 10k Accesses. 116 Citations. 61 Altmetric....
- Kristin Abramo, Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox, A. Nicole Fox, Job ...
- 2019
Anne-Laure Valton Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. View all articles by this author
- Denes Hnisz, Abraham S. Weintraub, Daniel S. Day, Anne-Laure Valton, Rasmus O. Bak, Charles H. Li, J...
- 2016
Abstract. Topologically Associating Domains (TADs) are conserved during evolution and play roles in guiding and constraining long-range regulation of gene expression. Disruption of TAD boundaries results in aberrant gene expression by exposing genes to inappropriate regulatory elements.
- Anne-Laure Valton, Job Dekker
- 2016
Abstract. Cohesin-mediated loop extrusion has been shown to be blocked at specific cis -elements, including CTCF sites, producing patterns of loops and domain boundaries along chromosomes. Here, we explore such cis -elements, and their role in gene regulation.
- 10.1038/s41594-022-00890-9
- 2022/12
Mar 3, 2016 · In summary, disruption of insulated neighborhood boundaries can cause oncogene activation in cancer cells. With maps of 3D chromosome structure such as those described here, cancer genome analysis can consider how recurrent perturbations of boundary elements may impact expression of genes with roles in tumor biology.
Abstract. Cohesin-mediated loop extrusion has been shown to be blocked at specific cis-elements, including CTCF sites, producing patterns of loops and domain boundaries along chromosomes. Here we explore such cis-elements, and their role in gene regulation.
