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Haspin (Hebrew: חַסְפִּין), widely known as Hispin, is a religious Israeli settlement organized as a community settlement located in the southern Golan Heights. The international community considers Israeli settlements in the Golan Heights illegal under international law, but the Israeli government disputes this. [2]
Aug 6, 2024 · NCBI Gene Summary for HASPIN Gene. Enables ATP binding activity and histone kinase activity (H3-T3 specific). Involved in histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; and mitotic sister chromatid cohesion.
Oct 6, 2021 · RNA sequencing reveals that haspin dosage affects severely the expression levels of several genes that are involved in male gametogenesis.
- Katerina Soupsana, Eleftheria Karanika, Fani Kiosse, Anastasia Christogianni, Yiorgos Sfikas, Pantel...
- 2021
May 1, 2022 · Haspin is a conserved atypical protein kinase that regulates chromosome dynamics, primary cilia and cellular polarization. It is overexpressed and required for cancer cell proliferation, and its inhibition or loss can affect tumor growth and metastasis.
Jan 14, 2020 · The kinase Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), creating a docking site for the Chromosomal Passenger Complex (CPC). CPC plays a pivotal role in preventing chromosome ...
- Eleftheria Karanika, Katerina Soupsana, Anastasia Christogianni, Dimitris Stellas, Apostolos Klinaki...
- 2020
Aug 23, 2023 · Here, we report that Haspin knockout (Haspin-KO) mouse embryonic stem cells (mESCs) had increased ratio of ACD, which cumulatively regulates cell fate decisions.
Oct 7, 2020 · Haspin is a serine/threonine kinase that associates with chromosome and phosphorylates threonine 3 of histone 3 during mitosis. Haspin overexpression or deletion results in defective mitosis. It has been shown that Haspin inhibitors have potent anti-tumoral effects.
