Search results
Amy E. Sheehan, Marc R. Freeman, Yang Xiang Correspondence yang.xiang@umassmed.edu In Brief Gu et al. demonstrate that heat and UVC light preferentially activate distinct Drosophila TrpA1 isoforms in vivo,and polymodal nociception requires co-expression of TrpA1-C and TrpA1-D. Gu et al., 2019, Current Biology 29, 3961–3973
Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Pengyu Gu, Jiaxin Gong, Ye Shang, Fei Wang, Kendra T. Ruppell, Zhiguo Ma, Amy E. Sheehan, Marc R. Freeman, Yang Xiang. Research output: Contribution to journal › Article › peer-review. 25 Scopus citations.
Dec 2, 2019 · Our results indicate that a given sensory stimulus preferentially activates a single TrpA1 isoform in vivo and that polymodal nociception requires co-expression of TrpA1 isoforms, providing novel insights of how alternative splicing regulates nociception.
- Pengyu Gu, Jiaxin Gong, Ye Shang, Fei Wang, Kendra T. Ruppell, Zhiguo Ma, Amy E. Sheehan, Marc R. Fr...
- 2019
Dec 12, 2019 · Here we develop a novel genetic approach to generate Drosophila knock-in strains expressing single TrpA1 isoforms. Drosophila TrpA1 mediates heat and UVC-triggered nociception. We show TrpA1-C and TrpA1-D, two alternative isoforms, are co-expressed in nociceptors.
- Pengyu Gu, Jiaxin Gong, Ye Shang, Fei Wang, Kendra T. Ruppell, Zhiguo Ma, Amy E. Sheehan, Marc R. Fr...
- 10.1016/j.cub.2019.09.070
- 2019
- 2019/12/12
Dec 2, 2019 · Drosophila TrpA1 mediates heat and UVC-triggered nociception. We show that TrpA1-C and TrpA1-D, two alternative isoforms, are co-expressed in nociceptors. When examined in heterologous cells, both TrpA1-C and TrpA1-D are activated by heat and UVC.
- Pengyu Gu, Jiaxin Gong, Ye Shang, Fei Wang, Kendra T. Ruppell, Zhiguo Ma, Amy E. Sheehan, Marc R. Fr...
- 2019
Oct 22, 2019 · TLDR. The discovery of a dTRPA1-dependent photochemical pathway that is sufficient to confer UV sensitivity to light-insensitive cells is described and two specific isoforms of TRPA1 in Drosophila are H2O2 sensitive and that they can detect strong UV light via sensing light-induced production of H 2O2. Expand.
Nov 16, 2022 · Here, we address these problems by investigating nocifensive behavior in Drosophila larvae. We show that strong poking stimulates nociceptors with a mixture of forces including shear stress and stretch. Unexpectedly, nociceptors are selectively activated by shear stress, but not stretch.
