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Progress in basic, preclinical, and clinical arenas spanning cellular immunology, synthetic biology, and cell-processing technologies has paved the way for clinical applications of chimeric antigen receptor-based therapies.
- Annual review of medicine
- 333-347
- 15
Chimeric antigen receptor (CAR) therapy is similar to an autologous bone marrow transplantation procedure. T cells are collected from the patient by apheresis, and the T cells are expanded and genetically modified using several approaches before they are returned to the patient.
- David M. Barrett, Nathan Singh, David L. Porter, Stephan A. Grupp, Carl H. June
- 10.1146/annurev-med-060512-150254
- 2014
- 2014
Progress in basic, preclinical, and clinical arenas spanning cellular immunology, synthetic biology, and cell-processing technologies has paved the way for clinical applications of chimeric antigen receptor-based therapies.
- David M. Barrett, Nathan Singh, David L. Porter, Stephan A. Grupp, Carl H. June
- 2014
May 1, 2014 · One of the first methods described involved culture of harvested lymphocytes with soluble anti-CD3 antibody (OKT-3) in the presence of interleukin (IL)-2 (18). This method has been used broadly and continues to be used in cell therapy trials today.
- David M. Barrett, Nathan Singh, Xiaojun Liu, Shuguang Jiang, Carl H. June, Stephan A. Grupp, Yangbin...
- 2014
Progress in basic, preclinical, and clinical arenas spanning cellular immunology, synthetic biology, and cell-processing technologies has paved the way for clinical applications of chimeric antigen receptor–based therapies.
Manmohan Singh ( Punjabi: [mənˈmoːɦən ˈsɪ́ŋɡ] ⓘ; born 26 September 1932) is an Indian retired politician, economist, academician and bureaucrat who served as the Prime Minister of India from 2004 to 2014. He is the fourth longest-serving prime minister after Jawaharlal Nehru, Indira Gandhi and Narendra Modi.
Stephan M. Singh is known for Ho Jai Ga (2017), Enjoy Your Flight! (2017) and Kinescoping Dr. Travis (2008).