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  1. Stiff-person syndrome (SPS), also known as stiff-man syndrome, [1] is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms, resulting in postural deformities.

  2. Jun 10, 2024 · Overview. What is stiff person syndrome? Stiff person syndrome (SPS) is a rare autoimmune neurological disorder that causes muscle stiffness in your trunk and abdomen (the middle part of your body). Over time, you may also develop stiffness (rigidity) and spasms in your legs and other muscles.

  3. Stiff person syndrome is a rare autoimmune neurological disorder that most commonly causes muscle stiffness and painful spasms that come and go and can worsen over time. However, some people experience other symptoms such as an unsteady gait, double vision or slurred speech. SPS symptoms are thought to be related to which type of SPS a person has.

  4. Jul 19, 2024 · Stiff-person syndrome (SPS) is a rare, progressive neurological disorder. Symptoms may include stiff muscles in the trunk (torso), arms, and legs; and greater sensitivity to noise, touch, and emotional distress, which can set off muscle spasms.

  5. Jul 10, 2023 · Stiff person syndrome (SPS) is a rare progressive and often underdiagnosed immune-mediated disorder of the central nervous system characterized by progressive rigidity and triggered painful spasms of predominantly axial and proximal limb muscles.

  6. Oct 11, 2024 · Formerly referred to as stiff man syndrome, SPS is a progressive condition that impacts the nervous system — the network the brain and spinal cord use to send messages all over the body and communicate with the muscles and senses. With SPS, the brain, spinal cord and muscles have difficulty communicating properly, leading to a range of symptoms.

  7. Jul 11, 2023 · Stiff person syndrome (SPS) is a rare acquired neurological disorder that most often causes progressive muscle stiffness (rigidity) and repeated episodes of painful muscle spasms. Muscular rigidity often fluctuates (i.e., grows worse and then improves) and usually occurs along with the muscle spasms.

  8. Stiff-person syndrome causes muscle stiffness that worsens gradually. Stiff-person syndrome often occurs in people with type 1 diabetes, certain autoimmune disorders, or certain kinds of cancer.

  9. Stiff Person Syndrome is an autoimmune and neurological disorder that causes rigidity and spasms in the trunk and limbs. Learn about symptoms and treatment.

  10. Stiff-person syndrome (SPS) is a progressive central nervous system disorder with a prevalence of one to two patients per million. The disease affects women two to three times more than men . SMP presents with muscle rigidity, which starts in the proximal muscles and progresses distally.