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  1. Smallpox is an acute contagious disease caused by the variola virus, a member of the orthopoxvirus family. It was one of the most devastating diseases known to humanity and caused millions of deaths before it was eradicated. It is believed to have existed for at least 3000 years. The smallpox vaccine, created by Edward Jenner in 1796, was the ...

  2. Aug 31, 2021 · Previously issued on: 31 August 2021Re-opening the call from 13 to 29 August 2022.WHO is re-opening the call for expressions of interest from experts to join the WHO Advisory Committee on Variola Virus Research (ACVVR) in order to attract additional candidates in the fields of public health, health security, biosafety, general vaccinology, diagnostic testing and therapeutics development. Women ...

  3. May 30, 2024 · The World Health Organization (WHO) Advisory Committee on variola virus Research (ACVVR), held its twenty-fifth meeting on 25-26 October 2023.

  4. The Advisory Committee for Variola virus Research (ACVVR) was convened in 1999 to implement WHA Resolution (WHA52). The ACVVR is composed of members from all WHO regions and advised by scientific academic experts from areas such as public health, fundamental applied research and regulatory agencies. About Meeting reports.

  5. The period since eradication has been defined by a lengthy, complex and unresolved debate focused on the destruction of the last remaining stocks of live variola virus. This global variola virus stock, consisting of isolates of both variola major and the milder form, variola minor, was restricted to 2 laboratories: the WHO Collaborating Centre on Smallpox and other Poxvirus Infections at the ...

  6. Jun 20, 2024 · Report of the World Health Organization (‎WHO)‎ Biosafety and Biosecurity Inspection Team of the Variola Virus Maximum Containment Laboratories to the Centers for Disease Control and Prevention (‎CDC)‎: Atlanta, Georgia, United States of America, 2-6 May 2022.

  7. Mar 6, 2009 · World Health Assembly resolution WHA60.1 (2007) mandates WHO to inspect the two authorized repositories for variola virus (CDC in Atlanta, GA, USA and VECTOR in Novosibirsk, Russian Federation) every two years to ensure that ‘the conditions of storage of the virus, and the research done in the laboratories meet the highest requirements of biosafety and biosecurity’.In addition, WHA60.1 ...

  8. Jun 28, 2016 · Smallpox is an ancient disease caused by the variola virus. Early symptoms include high fever and fatigue. The virus then produces a characteristic rash, particularly on the face, arms and legs. The resulting spots become filled with clear fluid and later, pus, and then form a crust, which eventually dries up and falls off.

  9. Jun 21, 2016 · Smallpox has two main forms: variola major and variola minor. The two forms showed similar lesions. The disease followed a milder course in variola minor, which had a case fatality rate of less than 1 per cent. The fatality rate of variola major was around 30%. There are two rare forms of smallpox: haemorrhagic and malignant.

  10. May 30, 2024 · The inspection was carried out at one of the two WHO-authorized variola virus (smallpox) repositories, the State Research Centre of Virology and Biotechnology (“VECTOR”) in the Russian Federation, in accordance with World Health Assembly resolution WHA60.1 (2007), as agreed by all relevant parties in a preparatory meeting before the visit.