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P19 cell is a pluripotent cell line derived from a mouse teratocarcinoma that can differentiate into cells of all three germ layers. It is widely used to study the mechanisms of drug-induced differentiation, especially neurogenesis and myogenesis, and the related signaling pathways.
RNA silencing suppressor p19 is a protein that binds to double-stranded RNAs and inhibits the antiviral RNA silencing system in plants. It is encoded by the ORF4 gene of tombusviruses, a family of positive-sense RNA viruses that infect plant cells.
Oct 2, 2020 · P19 binds sRNA duplexes and inhibits RNA silencing in a cell-autonomous manner (Silhavy et al., 2002; Vargason et al., 2003; Ye et al., 2003); notably, P19 also suppresses the intercellular spread of silencing, and this property is assumed to be the direct result of sRNA sequestration by the viral protein, an idea supported by ...
- Borja Garnelo Gόmez, Tabata Rosas‐Díaz, Chaonan Shi, Pengfei Fan, Dan Zhang, Jose S. Rufián, Rosa Lo...
- 19
- 2021
- 02 October 2020
May 1, 2003 · P19 cells are embryonal carcinoma cells derived from mouse teratocarcinomas that can differentiate into various cell types, including cardiomyocytes. This review summarizes the studies on P19 cells and their subclones that have contributed to our understanding of cardiac cell development and physiology.
- Marcel A.G. van der Heyden, Libert H.K. Defize
- 2003
Feb 8, 2000 · To inactivate either p16 INK4A or p19 ARF, we generated antisense RNA constructs that targeted exons 1α (p16αs) or 1β (p19αs), respectively, in replication-defective retroviruses .
- Amancio Carnero, James D. Hudson, Cathy M. Price, David H. Beach
- 2000
Mar 6, 2006 · In Nicotiana benthamiana plants infected with Tombusvirus that is devoid of P19 expression (ΔP19), RNAi is activated, leading to RISC-mediated degradation of viral RNA. In the presence of the...
P19 cells can be readily manipulated genetically, resulting in the loss or overexpression of a gene of interest. Because of this versatility, the P19 system is suited for examining the molecular methanisms controlling the developmental decisions of stem cells differentiating into the skeletal or cardiac muscle lineage.
